Hydroxypropyl beta cyclodextrin is a alkylated derivative of beta cyclodextrin. HP- beta -CD and beta -CD has not only the same envelope good effect for many compounds, improve stability of envelope material, and it has high water solubility and in vivo enhanced envelope drug release rate and bioavailability. Therefore, HP- beta -CD has some special advantages and is widely used in medicine. The introduction of hydroxypropyl groups breaks the intramolecular hydrogen bonds of beta cyclodextrin, while maintaining the cyclodextrin cavity and overcoming the major disadvantages of the poor water solubility of beta cyclodextrin. Is one of the most widely studied and widely used cyclodextrin derivatives. Mainly used in food, medicine, cosmetics industry.
HP- beta -CD can improve the stability and long-term efficacy of nutrition molecules in food and spice fields. It can cover or correct the bad smell and taste of food nutrition molecules, and can improve the production process and product quality.
HP- beta -CD in medicine, because the HP- beta -CD relative surface activity and hemolytic activity is relatively low and there is no stimulation to muscle, so it is an ideal injection solubilizing agent and pharmaceutical excipient. To improve the water solubility of insoluble drugs, increase the bioavailability of drugs, drug stability, the effect of adding or taking the medicine to reduce the amount of HP- beta -CD can release speed adjustment or control of drugs, reduce drug side effects. Can be used for oral medicine, injection, mucosal drug delivery system (including nasal mucosa, rectal, corneal etc.), transdermal drug delivery system, lipophilic drug targeting carrier, agent and stabilizer can also be used as a protective protein.
In the cosmetics raw materials of HP- beta -CD used as a stabilizer, emulsifier, deodorant, can reduce the stimulation of organic molecules in cosmetics on the skin mucous membrane, enhance the stability of the effective components, to prevent evaporation, oxidation of nutrients.
